THIOL REDOX RESEARCH in MOLECULAR NEUROLOGY

 

 

 

PUBLICATIONS

 

full text of most of the publications are available at researchgate

 

 

Original work and reviews

 

49.    Lepka, K., Volbracht, K., Bill, E.,Schneider, R., Rios, N., Hildebrandt, T., Ingwersen, J., Prozorovski, T.,

          Lillig, C.H., van Horssen, J., Steinman, L., Hartung, H.-P., Radi, R., Holmgren, A., Aktas, O.*, and Berndt,

          C.*

          Iron-sulfur Glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide released by

          activated microglia.

          Glia 65: 1521-1534 (2017)

 

48.    Berndt, C.*, and Lillig, C.H.*

          Glutathione, glutaredoxins, and iron.

          Antioxid. Redox Signal., accepted manuscript

 

47.    Egea J., Fabregat, I., Frapart, Y.M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U.G.,

          Lopez, M.G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S.,

          Afonso, C.B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M.M., Barbosa, R.M.,

          Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S.P., Brito, P.M., Carrara, G., Casas,

          A.I., Chatzi, A.,Chondrogianni, N., Conrad, M., Cooke,M.S., Costa, G.J., Cuadrado, A., My-Chan Dang, P.,

          De Smet, B., Debelec–Butuner, B., Dias, I., Dan Dunn, J., Edson, A.J., El Assar, M., El-Benna, J.,  

          Ferdinandy, P., Fernandes, A.S., Fladmark, K.S., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A.,

          Griffiths, H., Hampl, V.,Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S.,

          Jansen-Dürr, P., Jaquet, V., Joles, J.A., Kalyanaraman, B., Kaminskyy,D., Karbaschi, M., Kleanthous, M.,

          Klotz, L.O., Korac, B., Sami Korkmaz, K., Koziel, R., Kračun, D., Krause, K.H., Křen, V., Krieg, T.,

          Laranjinha,J., Lazou,A., Li, H., Martínez-Ruiz,A., Matsui,R., McBean, G.J., Meredith, S.P., Messens, J.,

          Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović,M., Monsalve, M., Mouthuy, P.A.,

          Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I.T.N.,  Oelze, M., Oliveira, N.G., Palmeira, C.M.,

          Papaevgeniou, N., Pavićević, A., Pedre, B., Peyrot,F., Phylactides, M., Pircalabioru, G.G., Pitt, A.R.,

          Poulsen, H.E., Prieto, I., Rigobello, M.P., Robledinos-Antón, N., Rodríguez-Mañas, L., Rolo, A.P., Rousset,

          F., Ruskovska, T., Saraiva, N., Sasson, S., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A.,

          Smith, G.L., Soldati, T., Sousa, B.C., Spickett, C.M., Stancic, A., Stasia, M.J., Steinbrenner, H., Stepanić,V.,

          Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentová, K., Varisli, L.,

          Veal, E.A., Yalçın, S., Yelisyeyeva, O., Žarković, N., Zatloukalová, M., Zielonka, J., Touyz, R.M.,

          Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H.H.H.W., Di Lisa, F., and Daiber, A.

          European contribution to the study of ROS: A summary of the findings and prospects for the future from

          the COST action BM1203 (EU-ROS).

          Redox Biol. 13: 94-162 (2017)

 

46.    Sies, H., Berndt, C., and Jones, D.P.

          Oxidative stress.

          Ann. Rev. Biochem. 86: 715-748 (2017)

          http://www.annualreviews.org/eprint/DyAxDXZmXtzJDJUmyeyh/full/10.1146/annurev-biochem-

          061516-045037

 

45.    Schneider, R., Koop, B., Schroeter, F., Cline, J., Ingwersen, J., Berndt, C., Hartung, H.-P., Aktas, O., and

          Prozorovski, T.

          Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune

          encephalomyelitis.

          Mol. Neurodegener. 11: 53 (2016)
 

44.    Lepka, K., Berndt, C.*, Hartung, H.-P., and Aktas, O.*

          Redox events as modulators of pathology and therapy of neuroinflammatory diseases.

          Front. Cell Dev. Biol. 4: 63 (2016)

 

43.    Bräutigam, L., Pudelko, L., Jemth, A.S., Gad, H., Narwal, M., Gustafsson, R., Karsten, S., Homan, E.,

          Berndt, C., Warpman-Berglund, U., Stenmark, P., and Helleday, T.

          Hypoxic signaling and the cellular tumor environment determine sensitivity to MTH1 inhbition.

          Cancer Res. 76: 2366-2375 (2016)

 

42.     Gascon, S., Murenu, E., Maserdotti, G., Ortega, F., Russo, G.L., Petrik, D., Desphande, A., Heinrich, C.,

           Karow, M., Robertson, S., Schroder, T., Beckers, J., Irmler, M., Berndt, C., Angeli, J.F., Conrad, M.,

           Berninger, B., and Götz, M.

           Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming.

           Cell Stem Cell 18: 396-409 (2016)

 

41.      Moseler, A., Aller, I., Wagner, S., Nietzel, T., Przybyla-Toscano, J., Mühlenhoff, U., Lill, R., Berndt, C.,

            Rouhier, N., Schwarzländer, M., and Meyer, A.

            The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation in

            Arabidopsis thaliana.

            Proc. Natl. Acad. Sci. USA 112: 13735-13740 (2015)

 

40.      Berndt, C., Schwenn, J.D., and Lillig, C.H.

            The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric    

            complementarity.

            Chem. Sci. 6: 7049-7058 (2015)

 

39.      Berndt, C.*, and Lillig, C.H.

            Redox regulation of differentiation and de-differentiation.

            Biochim. Biophys. Acta-General Subjects 1850: 1467-1468 (2015)

 

38.      Prozorovski, T., Schneider, R., Berndt, C., Hartung, H.P., and Aktas, O.

            Redox-regulated fate of neural stem progenitor cells.

            Biochim. Biophys. Acta-General Subjects 1850: 1543-1554 (2015)

 

37.      Gellert, M., Hanschmann, E.M., Lepka, K., Berndt, C., and Lillig, C.H.

            Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation.

            Biochim. Biophys. Acta-General Subjects 1850: 1575-1587 (2015)

 

36.      Knuesting, J., Riondet, C., Maria, C., Kruse, I., Becuwe, N., König, N., Berndt, C., Tourrette, S.,  

            Guilleminot-Montoya, Herrero, E., Gaymard, F., Balk, J., Belli, G., Scheibe, R., Reicheld, J.-P., Rouhier, N.,

            and Rey, P.

            Arabidopsis glutaredoxin S17 and its partner NF-YC11/NC2a contribute to maintenance of the shoot

            apical meristem under long-day photoperiod.

            Plant Physiol. 167: 1643-1658 (2015)

 

35.      Hildebrandt, T., Knuesting, J., Berndt, C., Morgan, B., and Scheibe, R.

            Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

            Biol. Chem. 396: 523-537 (2015)

 

34.      Berndt, C.*, Lillig. C.H., Flohé, L.

            Redox regulation by glutathion needs enzymes.

            Front. Pharmacol. 5: 168 (2014)

 

33.      Berndt, C.*, Poschmann, G., Stühler, K., Holmgren, A., and Bräutigam, L.*

            Zebrafish heart development is regulated via Glutaredoxin 2 dependent migration and  survival of neural

            crest cells.

            Redox Biol. 2: 673-678 (2014)

 

32.       Bräutigam, L.*, Jensen, L.D., Poschmann, G., Nyström, S., Bannenberg, S., Dreij, K., Lepka, K.,

             Prozorovski, T., Montano, S.J., Aktas, O., Uhlén, P., Stühler, K., Cao, Y., Holmgren, A., and Berndt, C.*

             Glutaredoxin 2 regulates vascular development by reversible glutathionylation of sirtuin1.

             Proc. Natl. Acad. Sci. U S A. 110: 20057-20062 (2013)

 

31.      Hanschmann, E.M., Godoy, J.R., Berndt, C., Hudemann, C., and Lillig, C.H.

            Thioredoxins, glutaredoxins, and peroxiredoxins – molecular mechanisms and health significance:

            from cofactors to antioxidants to redox signaling.

            Antioxid. Redox Signal. 19: 1539-1605 (2013) 

 

30.      Bräutigam, L., Johansson, C., Kubsch, B., McDonough, M.A., Bill, E., Holmgren, A.*, and Berndt, C.*

            An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin.

            Biochem. Biophys. Res. Commun. 436: 491-496 (2013)

 

29.      Haunhorst, P., Hanschmann, E.M., Bräutigam, L., Stehling, O., Hoffmann, B., Mühlenhoff, U., Lill, R.*,  

            Berndt, C.*, and Lillig, C.H.*

            Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.

            Mol. Biol. Cell 24: 1895-1903 (2013)

 

28.      Lillig, C.H., and Berndt, C.

            Cellular functions of glutathione

            Biochim. Biophys. Acta-General Subjects 1830: 3137-3138 (2013)

 

27.       Manta, B., Pavan, C., Sturlese, M., Medeiros, A., Crispo, M., Berndt, C., Krauth-Siegel, R.L., Bellanda, M.,

            and Comini, M.A.

            Iron-sulfur cluster (ISC) binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei:

            molecular basis of ISC coordination and relevance for parasite infectivity.

            Antioxid. Redox Signal. 19: 665-682 (2013)

 

26.       Lillig, C.H., and Berndt, C.*

            Glutaredoxins in thiol/disulfide exchange.

            Antioxid. Redox Signal. 18: 1654-1665 (2013)

 

25.      Bräutigam, L., Schütte, L.D., Godoy, J.R., Prozorovski, T., Gellert, M., Hauptmann, G., Holmgren, A., Lillig,

            C.H.*, and Berndt, C.*

            Vertebrate-specific glutaredoxin is essential for brain development.

            Proc. Natl. Acad. Sci, USA 108: 20532-20537 (2011)

 

24.      Berndt, C.*, Kurz, T., Bannenberg, S., Jacob, R., Holmgren, A., and Brunk, U.T.

            Ascorbate and endocytosed Motexafin gadolinium induce lysosomal rupture.

            Cancer Letters 307: 119-123 (2011)

 

23.      Hoffmann, B., Uzarska, M.A., Berndt, C., Godoy, J.R., Haunhorst, P., Lill, R., Lillig, C.H., and

            Muhlenhoff, U.

            The Multi-Domain Thioredoxin-Monothiol Glutaredoxins represents a Distinct Functional Group.

            Antioxid. Redox Signal. 15: 19-30 (2011)

 

22.      Berndt, C., Kurz, T., Selenius, M., Fernandes, A.P., Edgren, M.R., and Brunk,U.T.

            Chelation of lysosomal iron protects against ionizing radiation.

            Biochem. J. 432: 295-301 (2010)

 

21.      Ceylan, S., Seidel, V., Ziebart, N., Berndt, C., Dirdjaja,N., and Krauth- Siegel, R.L.

            The dithiol glutaredoxins of African trypanosomes have distinct roles and are closely linked to the

            unique trypanothione metabolism.

            J. Biol. Chem. 285: 35224-35237 (2010)

 

20.      Haunhorst, P., Berndt, C., Eitner, S., Godoy-Berthet, J.R., and Lillig, C.H.

           Characterisation of human Grx3 (PICOT) as FeS protein.

            Biochem. Biophys. Res. Commun. 394: 372-376 (2010)

 

19.      Lu, J., Berndt, C., and Holmgren, A.

           Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase.

           Biochim. Biophys. Acta-General Subjects 1790: 1513-1519 (2009)

 

18.     Zahedi Avval, F., Berndt, C., Pramanik, A., and Holmgren, A.

           Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd).

           Biochem. Biophys. Res. Commun. 379: 775-779 (2009)

 

17.      Comini, M.A., Rettig, J., Dirdjaja, N., Hanschmann, E.M., Berndt, C., and Krauth-Siegel, R.L.

            Monothiol Glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of african

            trypanosomes.

            J. Biol. Chem. 283: 27785-27798 (2008)

 

16.      Lillig, C.H., and Berndt, C.

            Preface to the special issue on redox regulation of cell function.

            Biochim. Biophys. Acta-General Subjects 1780: 1169 (2008)

 

15.      Lillig, C.H., Berndt, C., and Holmgren, A.

            Glutaredoxin systems.

            Biochim. Biophys. Acta-General Subjects 1780: 1304-1317 (2008)

 

14.      Berndt, C., Lillig, C.H., and Holmgren, A.

            Glutaredoxins and Thioredoxins as facilitators of protein folding.

            Biochim. Biophys. Acta-Mol. Cell Res.1783: 641-651 (2008)

 

13.      Hudemann, C., Berndt, C., and Lillig, C.H.

            Glutaredoxine und Eisen-Schwefel-Zentren.

            Biospektrum 14: 32-35 (2008)

 

12.      Lönn, M.E., Hudemann, C., Berndt, C., Cherkasov, V., Capani, F., Holmgren, A., and Lillig, C.H.

            Expression pattern of human glutaredoxin 2 isoforms: Identification and characterization of two

            testis/cancer cell-specific isoforms.

            Antioxid. Redox Signal. 10: 547-558 (2008)

 

11.      Su, D., Berndt, C., Fomenko, D.E., Holmgren, A., and Gladyshev, V.N.

            A conserved cis-proline precludes metalbinding by the active site thiolates in members of the

            thioredoxin family of proteins.

            Biochemistry 46: 6903-6910 (2007)

 

10.      Hashemy, I.S., Johansson, C., Berndt, C., Lillig, C.H., and Holmgren, A.

           Oxidations and S-nitrosylation of cysteins in human cytosolic and mitochondrial glutaredoxins.

           J. Biol. Chem. 282: 14428-14436 (2007)

 

9.        Berndt, C., Hudemann, C., Hanschmann, E.M., Axelsson,R., Holmgren, A., and Lillig, C.H.

           How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?

           Antioxid. Redox Signal. 9: 151-157 (2007)

 

8.         Berndt, C., Lillig, C.H., and Holmgren, A.

             Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in

             the cardiovascular system.

            Am. J. Physiol. Heart Circ. Physiol. 293: H1227-H1236 (2007)

 

7.         Holmgren, A., Johansson, C., Berndt, C., Lönn, M.E., Hudemann, C., and Lillig, C.H.

             Thiol redox control via thioredoxin and glutaredoxin systems.

             Biochem. Soc. Trans. 33: 1375-1377 (2005)

 

6.         Lillig, C.H., Berndt, C., Vergnolle, O., Lönn, M.E., Hudemann, C., Bill, E., and Holmgren, A.

            Characterization Of Human Glutaredoxin2 As New Iron-Sulfur Protein: A Possible Role As Redox

            Sensor.

            Proc. Natl. Acad. Sci. USA 102: 8168-8173 (2005)

 

5.         Fernandes, A.P., Fladvad, M., Berndt, C., Andresen, C., Lillig, C.H., Neubauer, P., Sunnerhagen, M.,

            Holmgren, A., and Vlamis-Gardikas, A.

            A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin

            reductase.

            J. Biol. Chem. 280: 24544-24552 (2005)

 

4.         Berndt, C., Lillig, C.H., Wollenberg, M., Bill, E., Mansilla, M.C., de Mendoza, D., Seidler, A., and

            Schwenn, J.D.

            Characterisation and Rekonstitution of a 4Fe-4S Adenylyl Sulfate/Phosphoadenylyl Sulfate Reductase

            from Bacillus subtilis.

            J. Biol. Chem. 279: 7850-7855 (2004)

 

3.         Wollenberg, M., Berndt, C., Bill, E., Schwenn, J.D., and Seidler, A.

             A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster

             between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins.

             Eur. J. Biochem. 270: 1662-1671 (2003)

 

2.         Rouhier, N., Vlamis-Gardikas, A., Lillig, C.H., Berndt, C., Schwenn, J.D., Holmgren, A., and Jacquot, J.P.

            Characterisation of the Redox Properties of Poplar Glutaredoxin.

             Antioxid. Redox Signal. 5: 15-22 (2003)

 

1.         Lillig, C.H., Schiffmann, S., Berndt, C., Berken, A., Tischka, R., and Schwenn, J.D.

            Molecular and catalytic properties of Arabidopsis thaliana adenylylsulfate-(APS)-kinase.

            Arch. Biochem. Biophys. 392: 301-310 (2001)

 

  

Published conference contributions

 

9.       Berndt, C., and Lillig, C.H.

           The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric

           complementarity and not by redox potential.

           FEBS J. 282: 110 (2015)

 

8.        Gellert, M., Berndt, C., Deponte, M., and Lillig, C.H.

            Redox control of cytosceletal dynamics: toggling the thiol switch in CRMP2.

            FEBS J. 282: 115 (2015)

 

7.        Lepka, K., Volbracht, K., Schaberg, E., Hartung, H.P., Goebels, N., Aktas, O., and Berndt, C.

           Glutaredoxin 2 increases oligodendroglial capacity for regeneration after neuroinflammatory damage.

           Glia 63: E421 (2015)

 

6.         Klose, J., Görg, B., Berndt, C., Häussinger, D., Aktas, O., and Prozorovski, T. 

            Protein oxidative damage in hippocampus in a mouse model of acut hyperammonemia.

            J. Clinic. Biochem. Nutr. 54: S97 (2014)              

 

5.         Lepka, K., Volbracht, K., Voevodskaya, N., Bill., E., Hartung, H.P., Holmgren, A., Aktas, O., and Berndt, C.

            Glutaredoxin 2 protects against oligodendroglial cell death during neuroinflammation.

            J. Clinic. Biochem. Nutr. 54: S49 (2014)     

 

4.         Bräutigam, L., Jensen, L.D.E., Poschmann, G., Lepka, K., Montano, S.J., Aktas, O., Stühler, K., Cao, Y.,

            Holmgren, A., and Berndt, C.

            Glutaredoxin 2 regulates vascular development by reversible glutathionylation of sirtuin 1.

            J. Clinic. Biochem. Nutr. 54: S42 (2014)

 

3.         Berndt, C., Lepka, K., Volbracht, K., Schneider, R., Hartung, H.P., Prozorovski, T., and Aktas, O.

            A vertebrate specific Glutaredoxin affects cellular functions of oligodendrocytes.

            Glia 61: S134-S135 (2013)

 

2.         Schneider R., Bosch, B., Schröter, F., Ingwersen, J., Berndt, C., Hartung, H.P., Prozorovski, T., and

            Aktas, O.

            Differential regulation of the Wnt signaling pathway in experimental autoimmune encephalomyelitis.

            Glia 61: S173-S174 (2013)

 

1.         Berndt, C., Hashemy, S.I., Hudemann, C., Voevodskaya, N., Bill, E., Joseph, B., Edgren, M., Lillig, C.H.,

             Brunk, U.T., and Holmgren, A.

             Iron-cofactors in members of the thioredoxin-family of proteins.

             Free Rad. Res. 40: S52 (2006)

 

  

Bookchapter

 

3.        Hanschmann, E.-M., and Berndt, C.

           Thioredoxin.

            in: "Encyclopedia of Signaling Molecules", 2nd edition, Choi, S., Ed., Springer (2017)

 

2.        Lillig, C.H., and Berndt, C.

           Thioredoxins and glutaredoxins. Functions and metal ion interactions.

           in: “Metal ions in life science” 5, A. Sigel, H. Sigel and R.K.O. Sigel, Eds., The Royal Society of Chemistry,

           Cambridge, UK, 413-439 (2009)

 

1.        Berndt, C., and Holmgren, A.

            Thioredoxins and the regulation of redox conditions in prokaryotes.

            in: “ Oxidative folding of cysteine-rich peptides and proteins”, J. Buchner, and L. Moroder, Eds., The

            Royal Society of Chemistry, Cambridge, UK, 2-18 (2008)